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Quadrupole-Linear Ion Trap Tandem Mass Spectrometry System for Clinical Biomarker Analysis Article

Xiang Fang, Jie Xie, Shiying Chu, You Jiang, Yuting An, Chang Li, Xiaoyun Gong, Rui Zhai, Zejian Huang, Chunling Qiu, Xinhua Dai

Engineering 2022, Volume 16, Issue 9,   Pages 56-64 doi: 10.1016/j.eng.2020.10.021

Abstract: In this study, a quadrupole-linear ion trap (Q-LIT) tandem mass spectrometer was designed and built inTarget precursor ions were first selected in the quadrupole, and then injected, trapped, and fragmented

Keywords： Linear ion trap     Quadrupole     Space charge effect Collision-induced dissociation     Biomarker    

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A Predictive Instrument for Sensitive and Expedited Measurement of Ultra-Barrier Permeation Article

Jianfeng Wanyan, Kun Cao, Zhiping Chen, Yun Li, Chenxi Liu, Runqing Wu, Xiao-Dong Zhang, Rong Chen

Engineering 2021, Volume 7, Issue 10,   Pages 1461-1470 doi: 10.1016/j.eng.2021.02.017

Abstract:

The reliable operation of flexible display devices poses a significant engineering challenge regarding the metrology of high barriers against water vapor. No reliable results have been reported in the range of 10-6 g∙(m2∙d)-1, and there is no standard ultra-barrier for calibration. To detect trace amount of water vapor permeation through an ultra-barrier with extremely high sensitivity and a greatly reduced test period, a predictive instrument was developed by integrating permeation models into high-sensitivity mass spectrometry measurement based on dynamic accumulation, detection, and evacuation of the permeant. Detection reliability was ensured by means of calibration using a standard polymer sample. After calibration, the lower detection limit for water vapor permeation is in the range of 10-7 g∙(m2∙d)-1, which satisfies the ultra-barrier requirement. Predictive permeation models were developed and evaluated using experimental data so that the steady-state permeation rate can be forecasted from non-steady-state results, thus enabling effective measurement of ultra-barrier permeation within a significantly shorter test period.

Keywords： Water vapor permeation     Ultra-barrier     Predictive model     Quadrupole mass spectrometer    

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Title Author Date Type Operation

Quadrupole-Linear Ion Trap Tandem Mass Spectrometry System for Clinical Biomarker Analysis

Xiang Fang, Jie Xie, Shiying Chu, You Jiang, Yuting An, Chang Li, Xiaoyun Gong, Rui Zhai, Zejian Huang, Chunling Qiu, Xinhua Dai

Journal Article

A Predictive Instrument for Sensitive and Expedited Measurement of Ultra-Barrier Permeation

Jianfeng Wanyan, Kun Cao, Zhiping Chen, Yun Li, Chenxi Liu, Runqing Wu, Xiao-Dong Zhang, Rong Chen

Journal Article